Retinoic Acid-Dependent Regulation of PDGF A Chain Expression (1994)

Title:

Retinoic Acid-Dependent Regulation of PDGF A Chain Expression

Key words:

retinoic acid. PDGF-A

Research Institution:

University of Illinois at Chicago

Location:

Illinois

Researcher:

Solita Chiayeng Wang

Project Description:

Dr. Wang investigated the basic mechanisms by which retinoic acid can regulate gene expression, in particular the expression of the PDGF-A chain. PDGF is a major growth regulator for connective tissues and glial cells. Dr. Wang has shown that PDGF is over-expressed in malignant brain tumors and that retinoic acid blocks PDGF-A protein expression during cell differentiation. She expanded her studies on this activity of retinoic acid and its role as an anti-cancer agent.