Role of Dietary Antioxidants in Free Radical Enhancement of Etoposide (VP-16) Antitumor Activity (1994)

Title:

Role of Dietary Antioxidants in Free Radical Enhancement of Etoposide (VP-16) Antitumor Activity

Key words:

vitamin E, vitacin C, BHT, BHA, etoposide VP-16, leukemia

Research Institution:

University of Pittsburgh

Location:

Pennsylvania

Researcher:

Valerian E Kagan

Project Description:

Dr. Kagan investigated the interaction between dietary antioxidants, vitamins C and E, BHT and BHA, and etoposide VP-16, a widely used phenolic antitumor drug. He sought to determine how different levels of these antioxidants may affect oxidative activation of VP-16 in K562 human leukemia cells and the extent of cytotoxicity of VP-16 in these cells.