Neural Cell Adhesion Molecule and Retinoic Acid Receptor Expression in Brain Tumors: Their Potential Roles in Metastasis and Adoptive Immunotherapy (1993)

Title:

Neural Cell Adhesion Molecule and Retinoic Acid Receptor Expression in Brain Tumors: Their Potential Roles in Metastasis and Adoptive Immunotherapy

Key words:

NCAM expression, retinoic acid

Research Institution:

University of Colorado at Denver

Location:

Colorado

Researcher:

Carol A Kruse

Project Description:

Neural cell adhesion molecule (NCAM) expression may be regulated by retinoic acid causing increased intercellular adhesion and a decreased ability for tumors to infiltrate the brain thereby decreasing potential metastatic tumors. Dr. Kruse examined the potential role of NCAMs in immunotherapy for astrocytomas and glioblastomas, two types of brain tumors.