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Non-invasive Detection of Colonic Cellular Markers: Modulation by Diet and Carcinogen (1993)

Title:

Non-invasive Detection of Colonic Cellular Markers: Modulation by Diet and Carcinogen

Key words:

protein kinase C

Research Institution:

Texas A & M University

Location:

Texas

Researcher:

Joanne R Lupton

Project Description:

In a previously funded AICR study, the investigator found a positive correlation between membrane protein kinase C and cell proliferation. In this study Dr. Lupton investigated the prognostic value of cell proliferation and protein kinase C in tumors. She sought to determine if intermediate markers, isolated cells from fecal material, can predict the neoplastic process. The markers tested included: protein kinase C, indicating malignant transformation, and p53 oncogene, which appears to regulate entry into and progression through the cell.

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