In a previously funded AICR study, the investigator found a positive correlation between membrane protein kinase C and cell proliferation. In this study Dr. Lupton investigated the prognostic value of cell proliferation and protein kinase C in tumors. She sought to determine if intermediate markers, isolated cells from fecal material, can predict the neoplastic process. The markers tested included: protein kinase C, indicating malignant transformation, and p53 oncogene, which appears to regulate entry into and progression through the cell.
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