Diacylglycerol Accumulation During Choline Deficiency: Mechanism for Hepatic Carcinogenesis (1989)

Title:

Diacylglycerol Accumulation During Choline Deficiency: Mechanism for Hepatic Carcinogenesis

Key words:

1,2-sn-diacylglycerol, choline definiency, protein kinase C

Research Institution:

Boston University

Location:

Massachusetts

Researcher:

Steven H Zeisel

Project Description:

Dr. Zeisel investigated how choline deficiency enhances liver cancer. He sought to determine if the excess 1,2-sn-diacylglycerol (1,2-DAG) that accumulates in the liver during choline deficiency might activate protein kinase C (PKC) and in this way lead to tumor initiation and promotion.