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Prevention of Malignant Phenotype Generation by Diet-administered Retinoids (1987)

Title:

Prevention of Malignant Phenotype Generation by Diet-administered Retinoids

Key words:

cachexia, retinoic acid, fat and protein metabolism

Research Institution:

Fox Chase Cancer Center

Location:

Pennsylvania

Researcher:

Douglas D Taylor

Project Description:

Dr. Taylor investigated whether vitamin A-like compounds could prevent the development of cachexia and the weakening of the immune system in cancer patients, a condition which appears to be caused by their tumors releasing certain metabolic inhibitors into general circulation which are then distributed to healthy tissues. These studies indicated that retinoic acid prevents alterations in fat and protein metabolism, decreases immune functions and cancer, as well as diminishes the growth of tumors and formation of metastases.

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