Over 50% of estrogen receptor positive (ER+) breast cancer patients who receive anti-estrogen therapy such as tamoxifen either never respond to the treatment or eventually develop resistance to it. Reversible epigenetic changes are associated with the development of anti-estrogen resistant breast cancer. However, reversal seems to occur only in individuals who acquired epigenetic change before breast cancer is detected. This study will investigate whether tamoxifen resistance in female rats exposed to a high-fat diet in utero can be prevented by life-long or adult dietary intake of genistein, or genistein intake that starts during tamoxifen treatment. Findings obtained in this study will help determine if genistein could prevent tamoxifen resistance and breast cancer recurrence in certain individuals.
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