Dr. Smith-Warner will examine whether men who eat foods that elevate insulin and glucose levels have a higher risk of advanced prostate cancer risk in the Pooling Project of Prospective Studies of Diet and Cancer. In a companion study, mice will be injected with prostate cancer cells and randomized to a diet with either no carbohydrates, a low-glycemic index Western diet, or a high-glycemic index Western diet. Relevant biomarkers and prostate cancer growth will then be compared. This proposal will strengthen the evidence for specific nutritional exposures in relation to cancer and will investigate mechanisms that link foods or dietary constituents to risk of advanced prostate cancer.
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