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Do-it-yourself chemoprevention: Can exercise increase circulating omentin levels to inhibit ovarian tumor recurrence and metastasis? (2015)

Title:

Do-it-yourself chemoprevention: Can exercise increase circulating omentin levels to inhibit ovarian tumor recurrence and metastasis?

Key words:

Research Institution:

University of Texas M.D. Anderson Cancer Center

Location:

Researcher:

Rosemarie Schmandt

Project Description:

Dr. Schmandt�s group will study omentin, a protein produced by belly fat and whose production is inhibited in the presence of tumor cells. Laboratory studies have shown that omentin slows the growth of ovarian cancer cells and prevents metastasis. If omentin production is blocked by tumor cells, then the re-induction of omentin synthesis by exercise may inhibit ovarian cancer progression and improve patient outcomes. This hypothesis will be tested using a mouse model of recurrent ovarian cancer. We anticipate that exercising animals will produce more omentin, dependent on their level of activity, and that their tumors will be slower growing. These studies will lay the groundwork for future clinical studies in human subjects.

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