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Targeted disruption of cancer cell metabolism and growth through modification of diet quality (2015)

Title:

Targeted disruption of cancer cell metabolism and growth through modification of diet quality

Key words:

Research Institution:

The University of Alabama at Birmingham

Location:

Researcher:

Barbara Gower

Project Description:

Cancer cells rely primarily on the use of glucose as a fuel. Growth of cancer cells is inhibited by substances called ketone bodies that are produced by healthy cells when fat is burned. Thus, it is possible that diets that promote use of fat as a fuel (ketogenic diets) could block cancer growth. Studies in mice have shown that ketogenic diets are able to slow cancer growth and decrease death from cancer. This study will investigate the effects of a ketogenic diet on cancer markers, tumor size, and metabolic variables in women with recurrent ovarian cancer. Therapies such as the ketogenic diet have the potential to become a valuable adjunct to standard cancer treatment.

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