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Epigenetics of early life exposure to cancer preventive cruciferous vegetables (2015)

Title:

Epigenetics of early life exposure to cancer preventive cruciferous vegetables

Key words:

Research Institution:

The University of Alabama at Birmingham

Location:

Researcher:

Trygve Tollefsbol

Project Description:

Dr. Tollefsbol�s group will use a mouse model to determine when in early life sulforaphane-rich cruciferous vegetables are most effective in preventing epigenetic alterations that can lead to breast cancer. Although the sulforaphane in foods such as broccoli sprouts has epigenetic effects that can help prevent breast cancer at concentrations, we do not yet know exactly how it works or when the best life course exposure is for optimal cancer protection. This study aims to pinpoint the optimal stages of early life that ample cruciferous vegetable exposure most effectively prevents epigenetic changes that lead to cancer and the mechanisms responsible for these effects.

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