GPx-1 Polymorphisms, Selenium and Cancer (2010)

Title:

GPx-1 Polymorphisms, Selenium and Cancer

Key words:

selenium, glutathione peroxidase-1, GPx-1 polymorphisms, DNA damage

Research Institution:

University of Illinois at Chicago

Location:

IllinoisUnited States

Researcher:

Anita 0 Jerome-Morais

Project Description:

This cell study is examining the hypothesis that individual differences in the gene sequence of a selenium-containing enzyme (GPx-1) determine how the enzyme interacts with selenium and its effectiveness in protecting cells from DNA damage that could lead to mutations and eventually result in cancer. The experiments plan on indicating the amount of dietary selenium certain individuals or subpopulations need for the greatest cancer-protective benefits.