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Epigenetics of Breast Cancer and Modulation by Bioactive Compounds (2010)

Title:

Epigenetics of Breast Cancer and Modulation by Bioactive Compounds

Key words:

BRCA1, epigenetics, nutrition

Research Institution:

University of Arizona

Location:

Arizona

Researcher:

Donato Romagnolo

Project Description:

This laboratory study is testing the hypothesis that dioxins and polycyclic aromatic hydrocarbons (PAHs) cause silencing of the tumor suppressor gene BRCA-1, and natural dietary compounds may prevent some of these mechanisms. Experiments include a series of molecular approaches to study modifications associated with the BRCA-1 gene in order to prevent the onset of sporadic breast cancers linked to silencing of the BRCA-1 gene.

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