Sign Up For Email Updates:

AICR Blog loading...
More from the blog »
WCRF/AICR
Global Network

Obesity-induced IGF-1 Coordinately Upregulates COX-2 and Downregulates Tumor Suppressive PGDH Resulting in Enhanced Pancreatic Cancer Growth (2010)

Title:

Obesity-induced IGF-1 Coordinately Upregulates COX-2 and Downregulates Tumor Suppressive PGDH Resulting in Enhanced Pancreatic Cancer Growth

Key words:

Obesity, pancreatic cancer, inflammation, COX-2, PGDH, prostaglandin, IGF-1

Research Institution:

University of Texas MD Anderson Cancer Center

Location:

Texas

Researcher:

Susan Fischer

Project Description:

This study is examining the hypothesis that the increased levels of insulin-like growth factor (IGF-1) caused by obesity alter the levels of several hormones and growth factors. The substances then lead to chronic inflammation, which may contribute to pancreatic cancer development. The study will treat specialized pancreatic cancer cells with IGF-1 and examine the levels of several substances in the pancreas of lean, overweight and obese mice and in mice that lack circulating IGF-1.

Cancer Site(s)

Related Foods that Fight Cancer

Questions: Ask Our Staff

Talk to us!

Our planned giving staff is
here to help you!

Richard Ensminger

Richard K. Ensminger

Director of Planned Giving

Ann Wrenshall Worley

Ann Wrenshall Worley

Assistant Director of Planned Giving

Call Us: (800) 843-8114

Send us a note