Dietary Induced Sporadic Colon Cancer (2009)

Title:

Dietary Induced Sporadic Colon Cancer

Key words:

Western diet, high-fat diet, calcium, vitamin D, choline, methionine, folate, fiber

Research Institution:

Montefiore Medical Center

Location:

New York

Researcher:

Leonard H Augenlicht

Project Description:

Much colon cancer is linked to consumption of diets that subtly alter the normal balance of the colonic mucosa and elevate the probability of a tumor forming over a long period of time. This study used a novel mouse model to examine the mechanism by which the Wnt signaling pathway is altered by nutritional factors present in a western diet (high in fat and low calcium, vitamin D, choline, methionine, folate and fiber).