Interaction Between Vitamin A and Phosphatidylinositol 3-kinase in Colorectal Tumor Metastasis (2008)

Title:

Interaction Between Vitamin A and Phosphatidylinositol 3-kinase in Colorectal Tumor Metastasis

Key words:

retinol, phosphatidylinositol 3-kinase

Research Institution:

Texas State University

Location:

Texas

Researcher:

Michelle Lane

Project Description:

This study tested the hypothesis that retinol (vitamin A) inhibits the metastasis of cancer cells through a unique post-translational mechanism involving inactivation of phosphatidylinositol 3-kinase (PI3K) enzyme. First, the effect was observed in mice consuming diets with vitamin A, and then it examined how vitamin A interacts with PI3K at the molecular level.