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Transcriptional Attenuation Induced by Sodium Butyrate and Vitamin D3 in Colon Cancer Cells (2008)

Title:

Transcriptional Attenuation Induced by Sodium Butyrate and Vitamin D3 in Colon Cancer Cells

Key words:

Vitamin D, butyrate

Research Institution:

Montefiore Medical Center

Location:

New York

Researcher:

Maria Cecilia Daroqui

Project Description:

Vitamin D and sodium butyrate, generated by the fermentation of dietary fiber are both regulators of colon maturation and gene expression. They regulate gene expression through a process called transcriptional attenuation. Since the mechanisms of transcriptional attenuation are largely unknown this study sought to examine and characterize the candidate genes for transcriptional attenuation using a novel, custom built microarray analysis to understand the nature and regulatory mechanisms recruited by two nutritional factors that coordinate colonic cell maturation.

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