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Epigenetic Effects of Genistein That May Prevent Later Cancer Development (2007)

Title:

Epigenetic Effects of Genistein That May Prevent Later Cancer Development

Key words:

maternal diet, methyl donors, phytoestrogens, genisten

Research Institution:

University of Missouri, Columbia

Location:

Missouri

Researcher:

Cheryl S Rosenfeld

Project Description:

This study investigated how maternal diet, fortifed with methyl donors and phytoestrogens, changes the onset and severity of adult disease. The goal of the study was to determine how genistein and methyl-supplemented diets methylate and thereby silence many gene promoters, whose expression otherwise results in cancer development and progression. An animal model with pre- and post-implantation of mouse embryos from dams on various diets was used.

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