Use of the Green Tea Polyphenol, Epigallocatchin-3-gallate, as a Novel Treatment for Trastuzumab Resistant Breast Cancer (2007)

Title:

Use of the Green Tea Polyphenol, Epigallocatchin-3-gallate, as a Novel Treatment for Trastuzumab Resistant Breast Cancer

Key words:

HER2/neu, EGCG, green tea polyphenols

Research Institution:

Boston University

Location:

Massachusetts

Researcher:

Nora Mineva

Project Description:

Trastuzumab has been used in clinical settings to block the HER2/neu activity. This postdoctoral application focused on EGCG and other green tea polyphenols as sensitizers and as effective agents in HER2/neu-resistant breast cancer cells. A mechanistic insight of their effcacy was sought by examination of the EGFR-mediated signalling pathways.