Detoxification of the Dietary Carcinogen N-hydroxy-PhIP: Variability in Human Colon and Relevance for Colon Cancer (2007)

Title:

Detoxification of the Dietary Carcinogen N-hydroxy-PhIP: Variability in Human Colon and Relevance for Colon Cancer

Key words:

PhIP, cooked meat, hydroxylamine metabolite

Research Institution:

University of Wisconsin at Madison

Location:

Wisconsin

Researcher:

Lauren A Trepanier

Project Description:

PhIP is a carcinogen formed from a chemical reaction in meat cooked at high temperature, causing colon cancer in rats through conversion to its hydroxylamine metabolite (NHOH-PhIP). This study examined the cellular mechanism by which NHOH-PhIP can be detoxifed by involvement of cytochrome b5 reductase (b5R) and cytochrome b5 (cyt b5), while single nucleotide polymorphisms (SNPs) account for variability in response.