Epigallocatechin-3-gallate for Enhancement of Cisplatin Therapy (2006)

Title:

Epigallocatechin-3-gallate for Enhancement of Cisplatin Therapy

Key words:

green tea, EGCG, cisplatin, AP-1, NF-?B, glutathione

Research Institution:

Temple University

Location:

Pennsylvania

Researcher:

Marion M Chan

Project Description:

This study determined whether EGCG, a major component of green tea, sensitises ovarian cancer cells to cisplatin treatment by inhibiting detoxifcation of cisplatin through inactivation of AP-1 and NF-?B pathways that could lead to the depletion of glutathione.