Direct Inhibitory Effect of Garcinol on FAK-Mediated Cancer Cell Survival (2006)

Title:

Direct Inhibitory Effect of Garcinol on FAK-Mediated Cancer Cell Survival

Key words:

garcinol, guttiferae, focal adhesion kinase activation

Research Institution:

Roswell Park Cancer Institute

Location:

New York

Researcher:

Adam Kisailus

Project Description:

This postdoctoral study examined the effect of Garcinol, a polyisoprenylated benzophenone found in the Guttiferae, to inhibit focal adhesion kinase (FAK) activation, in order to understand the FAK-related downstream signalling pathways and the mechanisms of Garcinol on apoptosis in cancer cells.