The Obesity-Cancer Link: Do Fatty Acids Promote the Tumorigenic Actions of IGF-1? (2005)

Title:

The Obesity-Cancer Link: Do Fatty Acids Promote the Tumorigenic Actions of IGF-1?

Key words:

oleate, palmitate, insulin-like growth factor, obesity

Research Institution:

Bristol University

Location:

United Kingdom

Researcher:

Jeff M.P. Holly

Project Description:

The effects of two fatty acids, oleate and palmitate, on the actions of insulin-like growth factor (IGF)-1 in breast cancer cells and in non-malignant breast epithelial cells were examined. IGFs have been strongly implicated as an important risk factor for many common cancers, including breast, and fatty acids are increased in the blood of obese individuals and are known to cause resistance to the actions of insulin.