Use of Novel Gentic Mouse Models to Investigate the Health Benefits of Folate in Colon Cancer (2005)

Title:

Use of Novel Gentic Mouse Models to Investigate the Health Benefits of Folate in Colon Cancer

Key words:

folate deficiency, gene expression, DNA methylation

Research Institution:

Texas A & M University

Location:

Texas

Researcher:

Robert S Chapkin

Project Description:

To investigate the folate defciency and increased risk of colon cancer, this study used a mouse model in which there was no folate binding protein to determine how this loss infuences colonic gene expression and DNA methylation following carcinogen (AOM) treatment.