Dietary Lipids and Hormones in Breast Carcinogenesis (2005)

Title:

Dietary Lipids and Hormones in Breast Carcinogenesis

Key words:

PPAR/RXR, retinoids

Research Institution:

University of Southern California

Location:

California

Researcher:

David L Crowe

Project Description:

This study tested whether dietary lipids and retinoids differentially promote interaction of PPAR/ RXR heterodimers with their coactivator proteins to regulate proliferation of normal human breast epithelial cells and breast cancer cell lines. The goal of this study was to provide insight into the roles of dietary fat and fat soluble hormones in prevention of breast cancer.