Lipid Modulation of Jak2-Stat5 Signal Transduction Pathway in Prostate Cancer (2003)

Title:

Lipid Modulation of Jak2-Stat5 Signal Transduction Pathway in Prostate Cancer

Key words:

omega-3, omega-6, PUFAs, chemotherapeutic nucleoside drugs

Research Institution:

Thomas Jefferson University

Location:

Pennsylvania

Researcher:

Marja Nevalainen

Project Description:

These studies were designed to examine the hypothesis that saturated and omega-6 polyunsaturated fatty acids enhance Jak2-Stat5 signal transduction in prostate cancer cells, thereby promoting their survival and proliferation, whereas omega-3 polyunsaturated fatty acids oppose Jak2-Stat5 signalling and reduce the growth of prostate cancer cells.