Corticotropin Releasing Hormone and Cancer Anorexia (2003)

Title:

Corticotropin Releasing Hormone and Cancer Anorexia

Key words:

corticotropin releasing hormone

Research Institution:

University of Cincinnati

Location:

Ohio

Researcher:

William T Chance

Project Description:

Many causes have been suggested for cancer anorexia but none have so far been able to explain the effects of a tumor on brain mechanisms that control feeding. This study sought to determine whether elevated levels of the brain peptide corticotropin releasing hormone (CRH), which inhibits feeding in fibrosarcoma tumor-bearing rats, promotes anorexia.