Prepubertal Soy Diet and Breast Cancer Risk: Role of Estrogen Receptors and Tumor Suppressor Genes (2002)

Title:

Prepubertal Soy Diet and Breast Cancer Risk: Role of Estrogen Receptors and Tumor Suppressor Genes

Key words:

soy, estradiol, prepuberty, estrogen

Research Institution:

Georgetown University

Location:

District of Columbia

Researcher:

Leena A Hilakivi-Clarke

Project Description:

Dr. Hilakivi-Clark examined the inhibitory effect of either prepubertal dietary soy or of prepubertal estradiol injection on carcinogen-induced mammary cancer in rats and mice, based on the hypothesis that up regulation of estrogen receptor beta and of the tumor suppressor gene BRCA1 are involved in the effect.