Bryan Fuchs, PhD
Massachusetts General Hospital
Green tea's EGCG may protect against liver cancer
In previous animal studies, Fuchs found that a gene called epidermal growth factor (EGF), promoted liver cancer growth.
Other studies have suggested that EGCG, a phytochemical rich in green tea, may inhibit EGF signaling. Putting those two findings together, Fuchs is using an animal model of chronic liver disease to determine whether EGCG inhibits the development of liver cancer by inhibiting cirrhosis. He is testing EGCG alone and in combination with erlotinib, a common treatment for the disease, to determine if it slows tumor progression.
"If EGCG is successful and we can prevent [liver cancer] from occurring in the first place, then the implications are huge,” says Fuchs.